Codeine and its salts are very well absorbed adhering to each oral and parenteral administration. Codeine is about ⅔ as productive orally as parenterally. Codeine is metabolized generally in the liver by enzymes of the endoplasmic reticulum, the place it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Small children Postmarketing circumstances of respiratory despair, including fatalities, are claimed with usage of promethazine in pediatric clients. Concomitant administration with other respiratory depressants could improve the threat of respiratory depression.
Convey to your health practitioner If you're pregnant or Consider you may be pregnant. All through pregnancy, this product isn't recommended. It might hurt an unborn newborn. Talk with your physician about the pitfalls and advantages of this medication. See also Warning section.
Signals and indications of overdosage with promethazine HCl vary from delicate depression on the central anxious program and cardiovascular method to profound hypotension, respiratory despair, unconsciousness, and sudden death.
Maintain out from the get to of youngsters and pets. This medication could be abused. Preserve it in a secure put to shield it from theft. Never share it with any one. It is only for yourself. Marketing or giving freely this medication is harmful and towards the regulation.
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Codeine Codeine is undoubtedly an opioid agonist somewhat selective for your mu-opioid receptor, but using a Significantly weaker affinity than morphine. The analgesic and antitussive Houses of codeine are already speculated to come from its conversion to morphine.
If somebody has overdosed and has critical signs and symptoms for instance passing out or problems respiratory, contact 911. Or else, call a poison control Centre straight away.
A possibly lethal symptom intricate occasionally referred to as Neuroleptic Malignant Syndrome (NMS) continues to be noted in Affiliation with promethazine HCl by itself or in combination with antipsychotic medications.
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g., amiodarone, quinidine) could cause a rise in codeine plasma concentrations along with a lessen in Lively metabolite morphine plasma concentration which could lead to an analgesic efficacy reduction or indications of opioid withdrawal.
Codeine is changed into a strong opioid drug (morphine) in your body. In some individuals, this transformation transpires speedier and even more fully than standard, which increases the chance of quite really serious Unwanted side effects.
Printed studies with codeine have noted inconsistent results and also have essential methodological limits (see Data). You will discover reports of respiratory despair when codeine is applied for the duration of labor and shipping (see Scientific Criteria).
Dosing The dose of this drugs is going to be distinctive for different sufferers. Comply with your medical doctor's orders or even the Instructions over the label. The subsequent information and Promethazine codeine syrup facts features only the normal doses of the medicine. If your dose differs, usually do not change it Unless of course your health practitioner lets you know to take action.